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The circadian clock protein Period 1 regulates expression of the renal epithelial sodium channel in mice
The body clock protein Period 1 controls salt channel levels in mouse kidneys
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Abstract
Aldosterone treatment increased expression of Period 1 mRNA in renal collecting duct cell lines and in the rodent kidney.
- Period 1 is the transcript most significantly induced by aldosterone in renal cells.
- RNA silencing of Period 1 significantly reduced the mRNA levels of the epithelial sodium channel (alphaENaC), regardless of aldosterone presence.
- Mice with a disrupted Per1 gene showed reduced alphaENaC mRNA expression and higher urinary sodium excretion.
- The expression of alphaENaC mRNA exhibited a circadian pattern that was disrupted in mice lacking functional Period genes.
- These findings indicate a potential role for Period 1 in regulating sodium transport in the kidneys.
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