Opposite roles of Per1 and Cry2 in controlling Per1-related gene activity in the liver and kidney

Per1 may activate renal and hepatic target genes through a mechanism that involves antagonizing Cry2.

• The circadian clock is involved in regulating blood pressure, kidney function, and metabolism.
• Per1 appears to contradict its known role as a repressor by activating genes crucial for kidney sodium reabsorption.
• Per1 knockout mice show reduced blood pressure and increased body weight, similar to Clock knockout mice but opposite to Cry1/2 knockout mice.
• Per1 is associated with the repression of Cry2, suggesting a complex role in gene regulation.
• The genes αENaC and Fxyd5 were identified as targets of Clock influenced by Per1 in kidney cells.
• Novel targets of Per1 identified in liver cells include PPARα and DEC1, with Per1 knockdown leading to increased Cry2 levels.

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