The American journal of pathology

Smad3 Limits Epithelial Cell Movement and Growth Through the Clock Gene Dec1, Which Reduces Other Clock Gene Activity

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Abstract

Smad3 knockout mice exhibited a decreased locomotor activity amplitude and reduced Dec1 expression in multiple tissues.

  • Dec1 expression decreased in the suprachiasmatic nucleus, liver, kidney, and tongue of Smad3 knockout mice.
  • Increased expression of Dec2 and Per1 was observed in Smad3 knockout mice compared to controls.
  • Immunohistochemical analysis showed decreased Dec1 and increased Dec2 and Per1 expression in the endothelial cells of the kidney and liver in Smad3 knockout mice.
  • Smad3 overexpression in NIH3T3 cells increased Dec1 expression while decreasing Dec2 and Per1 expression.
  • In a wound-healing experiment, reduced Dec1 expression in Smad3 knockout mice accelerated mucosal wound healing.
  • Dec1 overexpression reduced E-cadherin and proliferating cell nuclear antigen expression, while Dec2 overexpression had the opposite effect.

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