FEBS letters

The Body's Internal Clock and Skin Diseases

Updated

Abstract

The circadian clock in skin is influenced by various factors including feeding time, which may affect skin functions.

  • The internal rhythm of organisms is synchronized with the light-dark cycle, operating on a period of around 24 hours.
  • Light signals from the retina play a key role in setting the timing of the circadian clock in the brain's suprachiasmatic nucleus.
  • Feeding time has a significant impact on the skin circadian clock and its related functions, an area previously overlooked.
  • Disruption of the circadian clock is associated with various skin diseases, including skin cancer, aging, and inflammatory conditions.
  • Circadian medicine shows potential for preventing and managing skin diseases by aligning treatment with the body's internal clock.

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