Circadian timing of metabolism in animal models and humans

Almost every cell in the body possesses its own circadian timekeeper that may regulate key metabolic processes.

• The circadian timing system in mammals coordinates various physiological processes, including metabolism and endocrine functions.
• A master pacemaker in the suprachiasmatic nucleus of the hypothalamus synchronizes daily rhythms to environmental light cycles.
• Peripheral organ clocks are influenced by feeding cycles, body temperature, and bloodborne signals.
• Circadian clocks in peripheral tissues may orchestrate food processing and detoxification processes.
• Circadian misalignments, such as those from shiftwork or social jet lag, could be linked to the development of metabolic disorders and certain cancers.

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