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Regulatory links between the circadian clock and stress-induced biomolecular condensates
How the body’s internal clock controls stress-related protein clusters
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Abstract
The may regulate stress granule formation and mRNA translation across eukaryotes.
- Circadian rhythms influence the dynamics of , which are RNA-protein assemblies involved in cellular stress responses.
- In animals and fungi, key factors like eIF2α are controlled by the circadian clock to manage mRNA sequestration and translation rhythms.
- Plants exhibit rhythmic translation of some transcripts from arrhythmic expression, suggesting additional regulation mechanisms by the circadian clock.
- Certain clock-controlled genes are induced by heat stress only at the transcriptional level, indicating a complex regulatory layer beyond transcription.
- The review emphasizes the potential role of in linking the circadian clock to stress tolerance in plants.
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