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A circadian clock translational control mechanism targets specific mRNAs to cytoplasmic messenger ribonucleoprotein granules
A body clock mechanism controls certain mRNAs by sending them to cytoplasmic RNA storage granules
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Abstract
Approximately 14% of mRNAs are rhythmically translated in wild-type Neurospora crassa cells.
- Translation rhythms for about 30% of these mRNAs, termed circadian translation-initiation-controlled genes (cTICs), depend on the biological clock and the CPC-3 kinase.
- Most cTICs are derived from mRNAs that do not show rhythmic expression and contain a specific motif that directs their localization to processing bodies.
- Deletion of SNR-1, a component of certain cytoplasmic RNA granules, disrupts the rhythmic translation of the cTIC mRNA zip-1.
- Findings suggest that the biological clock may influence the translation of specific mRNAs through the regulation of eIF2α phosphorylation and the metabolism of cytoplasmic RNA granules.
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