Physiological reviews

Kidney's internal daily clocks: how they work and are controlled

Updated

Abstract

Circadian rhythms in renal function are an integral part of kidney physiology.

  • Nearly every cell in the body contains an intrinsic cellular circadian clock.
  • Peripheral circadian clocks in kidney cells help regulate various renal processes.
  • Extrarenal physiological processes, including endocrine and neuronal signals, may impact kidney function.
  • The role of time of day as a key biological variable is significant in kidney physiology.
  • Current understanding of kidney clocks is limited, highlighting the need for further investigation.

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