We can’t show the full text here under this license. Use the link below to read it at the source.
Circadian Control of Neutrophils Drives Collateral Perfusion and Stroke Outcome
The body's internal clock may influence neutrophils, affecting blood flow and stroke results.
AI simplified
Abstract
Infarct volume and neurological deficits in stroke may exhibit clear circadian oscillations, with worse outcomes during the inactive phase.
- Stroke outcomes could be more severe when occurring during the murine inactive phase (Zeitgeber time 5) compared to the active phase (Zeitgeber time 13).
- Neutrophils during the inactive phase may adopt an activated, NET-prone state, leading to reduced collateral perfusion and microvascular stalling.
- Depletion of neutrophils or disruption of circadian clocks appears to eliminate the observed time-of-day effects on stroke outcomes.
- In a cohort of 540 ischemic stroke patients, neutrophil and NET-related biomarkers exhibit diurnal patterns, peaking during the evening/night, which may correlate with poorer collateral flow and outcomes.
- Inhibiting NET formation through pharmacological means or genetic deletion may restore collateral perfusion and mitigate the time-of-day effects on stroke severity.
AI simplified
Key numbers
2.3×
Increase in infarct volume
Infarct size at ZT5 vs. ZT13 in mouse models.
50%
Reduction in infarct volume
Comparison of infarct volume in treated vs. untreated mice at ZT5.
366
Patient cohort size
Total number of stroke patients analyzed for diurnal variations.