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Circadian control of tumor immunosuppression affects efficacy of immune checkpoint blockade
Daily body clock influences tumor immune suppression and response to immune checkpoint therapy
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Abstract
Circadian control influences the abundance of immunosuppressive cells, particularly PD-L1-expressing myeloid-derived suppressor cells (MDSCs), in colorectal cancer.
- The immune landscape is modulated by circadian rhythms, affecting host defense and tumor immunosurveillance.
- Single-cell RNA sequencing reveals clock-dependent changes impacting cytotoxic CD8T cell suppression.
- PD-L1-expressing MDSCs exhibit rhythmic peaks in abundance, suggesting a timed pattern of immunosuppression.
- Disruption of the epithelial cell clock leads to increased cytokine secretion, promoting inflammation and MDSC development.
- Timing of anti-PD-L1 treatment is more effective when aligned with MDSC abundance.
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