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Abstract
Circadian rhythms significantly affect the quality and quantity of tumor-infiltrating lymphocytes, particularly CD8T cells.
- Tumor-infiltrating lymphocytes display daily cycles influenced by the body's internal clock and the clock of endothelial cells in the tumor area.
- Modifying the timing of treatments like chimeric antigen receptor T cell therapy and immune checkpoint blockade may enhance their effectiveness.
- Circadian-dependent patterns in T cells from mouse models are linked to overall survival in melanoma patients.
- Responses to anti-PD-1 therapy correlate with specific time-of-day T cell signatures.
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