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Abstract
Circadian dysfunction in Parkinson's disease is associated with alterations in clock gene expression and melatonin secretion.
- Pathological lesions affecting circadian regulation may lead to circadian disruption in patients with Parkinson's disease.
- Reduced neuronal firing in the central pacemaker could influence clock gene expression and melatonin rhythms.
- Motor and non-motor symptoms in Parkinson's disease may include sleep disorders, autonomic dysfunction, and depression.
- Therapeutic options such as light therapy, melatonin, and behavioral strategies may address circadian rhythm disorders.
- The genetic basis for circadian disruption in Parkinson's disease is not fully understood, and overlapping symptoms may complicate the underlying neuropathophysiology.
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