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The role of circadian disruption, sleep dysregulation, lifestyle factors, and metabolic reprogramming in the pathogenesis and progression of ovarian cancer
How disrupted body clocks, poor sleep, lifestyle, and metabolism changes may contribute to the development and growth of ovarian cancer
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Abstract
Disruption of the circadian clock has been associated with tumorigenesis, metabolic imbalance, and chemoresistance in ovarian cancer.
- Circadian rhythms, metabolic changes, and lifestyle factors play significant roles in ovarian tumor behavior.
- Ovarian cancer cells exhibit increased glycolysis and glutaminolysis to support their growth and survival.
- Lifestyle factors like diet, physical inactivity, obesity, and stress may influence cancer risk and treatment outcomes.
- Genetic dysregulation and lifestyle habits such as night-shift work can disrupt the circadian clock.
- Strategies like chronotherapy and metabolic targeting are being explored to enhance treatment effectiveness.
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