Daily biological rhythms influence the spread of cancer
Updated
Abstract
Circadian disruption may promote tumor progression by altering the tumor microenvironment.
- Circadian rhythms regulate gene expression that influences various physiological functions.
- Disruption of circadian rhythms can lead to increased cancer cell proliferation and altered cell death processes.
- Circadian control affects the dynamics of the tumor microenvironment, impacting cancer metastasis.
- Matrix metalloproteinases involved in extracellular matrix remodeling show circadian oscillation, affecting collagen structure.
- Cytokine secretion by cancer-associated cells follows a rhythmic pattern that influences the movement of cancer cells into the bloodstream.
- Daily variations in adhesion molecules on blood vessel surfaces are linked to the timing of cancer cell migration.
Simplified
Funding
Competing interests
No potential conflicts of interest are disclosed.
PubMed