Role of the frequency gene in controlling the biological clock of Neurospora

Experiments indicate that inputs to circadian clocks can be regulated in a rhythmic manner.

• Circadian clocks are composed of inputs, an oscillator, and outputs that manage circadian rhythms.
• Assigning specific molecular components to these elements is challenging.
• Mathematical simulations suggest that altering the expression levels of certain gene products may lead to disrupted rhythms, regardless of their role in the oscillator or input pathways.
• Traditional circadian entrainment protocols were applied to the genetic model system, Neurospora crassa, to further explore these dynamics.

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