Antisense RNA's role in controlling the daily biological clock in Neurospora crassa

Antisense RNA may influence circadian clock regulation in the model organism Neurospora crassa.

• Antisense RNA from a clock component locus is associated with the control of the circadian clock.
• In wild-type strains, antisense frequency (frq) transcripts show antiphase cycling to sense frq transcripts in the dark.
• Light induces the expression of antisense frq RNA, impacting the timing of the internal clock.
• In mutant strains lacking light-induced antisense frq RNA, the circadian clock is delayed compared to wild-type strains.
• These findings suggest a broader role for antisense RNA in regulating eukaryotic cellular processes.

Simplified