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Transcriptional interference by antisense RNA is required for circadian clock function
Antisense RNA blocking gene activity is needed for the body’s internal clock to work
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Abstract
Transcription of the long non-coding frq antisense RNA (qrf) is induced by light and oscillates in antiphase to the frq sense RNA.
- qrf transcription is regulated by both light-dependent and light-independent mechanisms.
- Light-dependent qrf transcription represses frq expression and is involved in clock resetting.
- Light-independent qrf expression is necessary for maintaining circadian rhythmicity.
- frq transcription inhibits qrf expression, contributing to the antiphasic rhythm of qrf transcripts.
- The interaction between frq and qrf transcription forms a double negative feedback loop that supports sustained circadian rhythms.
- Antisense transcription may inhibit sense expression through chromatin modifications and premature termination.
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