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Circadian gene expression of clock genes and plasminogen activator inhibitor-1 in heart and aorta of spontaneously hypertensive and Wistar–Kyoto rats
Daily patterns of clock gene and blood clotting inhibitor activity in the heart and main artery of high blood pressure and normal rats
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Abstract
Cardiac PAI-1 expression was high in the dark, while aortic PAI-1 expression was high in the light.
- Cardiac PAI-1 expression levels were greater in spontaneously hypertensive rats (SHR) compared to Wistar-Kyoto (WKY) rats.
- Candesartan treatment reduced cardiac PAI-1 expression specifically during the dark period in WKY rats and throughout the day in SHR.
- Candesartan significantly attenuated the daily fluctuations of aortic PAI-1 mRNA in both SHR and WKY rats, while hydralazine did not.
- Clock genes showed synchronized oscillation patterns in both the heart and aorta of SHR and WKY rats.
- In SHR, clock gene expression was elevated in the heart but remained unchanged in the aorta.
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