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Daily Patterns of Gene Activity in Ligament Cells During Orthodontic Pressure
Updated
Abstract
Essence
Human periodontal ligament cells showed time-dependent circadian gene expression after simulated orthodontic compressive force.
Evidence
Cell-culture experiment exposed primary hPDLFs to 2 g/cm² compressive force for 24 hours and measured circadian gene expression by quantitative RT-PCR at five time points.
Caveat
The findings come from an in vitro 24-hour force model with malformed abstract reporting of several gene names and statistics, not clinical orthodontic outcomes.
Simplified
Key numbers
2.31 ± 0.41-fold
Peak Expression Increase of BMAL1 and CLOCK
Measured at 12 hours post-force application
2.44 ± 0.39-fold
Peak Expression Increase of PER1 and CRY1
Measured at 18 hours post-force application
-0.76
Strong Inverse Correlation
Correlation between BMAL1 and PER1 expression
Circadian Biology