Circadian gene expression in peripheral blood leukocytes of rotating night shift nurses

May 4, 2012Scandinavian journal of work, environment & health

Daily cycle gene activity in blood cells of nurses working rotating night shifts

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Abstract

There were no statistically significant changes in circadian gene expression among 184 nurses and midwives working rotating night shifts compared to those working day shifts.

  • The highest expression of the PER1 gene was noted in women working more than 15 years of rotating night shifts.
  • A significant association was found between PER1 gene expression and the total duration of rotating night shift work among current night shift workers (P=0.04).
  • PER1 and PER3 gene levels were significantly lower in blood samples taken later in the morning (06:00-10:00 hours) compared to earlier times, indicating potential time-of-day effects (β-coefficient -0.226, P=0.001 for PER1 and β-coefficient -0.181, P<0.0001 for PER3).
  • Current rotating night shift work does not appear to affect circadian gene expression in peripheral blood leukocytes.

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