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Pressure Building Against the Clock: The Impact of Circadian Misalignment on Blood Pressure
How Body Clock Disruption May Raise Blood Pressure
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Abstract
Circadian misalignment, particularly from shift work, alters 24-hour blood pressure rhythms.
- Circadian misalignment affects blood pressure regulation through changes in the autonomic nervous system and sodium retention.
- Disruption of endothelial function and activation of proinflammatory processes may also be involved in altered blood pressure rhythms.
- Social jetlag does not directly affect blood pressure levels in healthy adults but may increase hypertension risk through sympathetic activation or obesity.
- Assessment of social jetlag could be valuable in shift work populations, where circadian misalignment may be more pronounced.
- Interventions such as light therapy, melatonin supplementation, and adjusted drug timing may improve cardiovascular outcomes related to circadian misalignment.
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