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Circadian Regulation of Drug Responses: Toward Sex-Specific and Personalized Chronotherapy
Body Clock's Role in Drug Responses: Moving Toward Personalized Treatments Based on Sex and Timing
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Abstract
Significant improvements in medication tolerability and efficacy have been confirmed through proper administration timing for various treatments.
- Integration of molecular clocks is essential for advancing personalized chronotherapy in precision medicine.
- Recent studies indicate that drug responses may differ between sexes due to circadian rhythms.
- Dedicated randomized clinical trials are necessary to develop personalized circadian timing recommendations for clinical practice.
- Innovative technologies could facilitate remote monitoring of circadian metrics and predict molecular clock function from single-timepoint biopsies.
- Patients with strong circadian function may benefit most from personalized chronotherapy, while those with poor circadian function might find relief through chronobiotics.
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