How the Body’s Internal Clock Controls Metabolism in Health and Disease

Circadian dysregulation may independently increase the risk of insulin resistance, obesity, and diabetes.

• Circadian rhythms in mammals are regulated by a feedback loop involving core transcription factors.
• These transcription factors also influence metabolism-related genes in specific tissues.
• Feeding behavior and physical activity can affect the circadian clock, indicating a two-way relationship with metabolism.
• Key metabolic organs, such as pancreatic β cells, skeletal muscle, liver, and adipose tissue, are regulated by circadian mechanisms.
• Exploring the relationship between the circadian clock and metabolism could lead to new therapeutic strategies for metabolic disorders.

Simplified