Daily timing of salt intake changes gene activity controlling salt processing in the colon

Timed salt intake reshaped colonic circadian and mineralocorticoid pathways that track sodium handling and blood-pressure rhythms in nocturnal mice.

This was a mechanistic animal study combining diet timing and salt level in mice with colonic gene-rhythm, aldosterone, MR-BMAL1 occupancy, peripheral clock, sodium absorption, and blood-pressure measurements.

The key contrast pairs nighttime low-salt feeding with daytime high-salt feeding in mice, limiting separation of timing from salt amount and translation to human blood-pressure control.