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Adrenal-Specific KO of the Circadian Clock Protein BMAL1 Alters Blood Pressure Rhythm and Timing of Eating Behavior
Removing a Key Body Clock Protein in the Adrenal Glands Changes Daily Blood Pressure Patterns and Meal Timing
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Abstract
Male adrenal-specific knockout mice exhibit a shortened blood pressure cycle by approximately 1 hour.
- Adrenal-specific knockout of BMAL1 leads to a delayed peak in blood pressure and activity by about 2 and 3 hours, respectively.
- Knockout mice show increased serum corticosterone levels when housed in metabolic cages compared to home cages.
- Altered diurnal variation in serum corticosterone is observed in knockout mice.
- Knockout mice have a blunted night/day ratio of food intake, despite no change in total food consumption.
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Key numbers
23 h 30
Shortened BP Circadian Cycle
BP period in KO mice compared to controls
2 h
Delayed BP Peak
Acrophase shift in KO mice vs. controls
0.0008
Reduced Night/Day Ratio of Food Intake
Night/day food intake ratio in KO mice vs. controls