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The Molecular Circadian Clock of Phox2b-expressing Cells Drives Daily Variation of the Hypoxic but Not Hypercapnic Ventilatory Response in Mice
Daily Clock in Specific Brain Cells Affects Low Oxygen but Not High Carbon Dioxide Breathing Responses in Mice
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Abstract
BMAL1 knockout mice exhibited blunted daily rhythms in ventilation and failed to show daily variation in hypoxic and hypercapnic ventilatory responses.
- The suprachiasmatic nucleus is linked to daily changes in breathing patterns.
- BMAL1 knockout mice showed reduced daily variation in minute ventilation compared to wild-type mice.
- BMAL1 knockout mice did not exhibit daily variation in hypoxic or hypercapnic ventilatory responses.
- Mice lacking BMAL1 specifically in chemoreceptor cells displayed normal circadian variations in minute ventilation and hypercapnic responses.
- The molecular clock in Phox2b-expressing cells is crucial for daily variation in the hypoxic ventilatory response.
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Key numbers
0.0001
Decrease in Daily Rhythm of Minute Ventilation
P-value from analysis of variance comparing BMAL1 KO to wild-type mice.
8
Lack of Daily Variation in HVR
Number of male BKOP mice assessed for HVR.
7
Significant Day-Night Difference in HCVR
Number of male wild-type mice assessed for HCVR.