Differences in renal BMAL1 contribution to Na ⁺ homeostasis and blood pressure control in male and female mice

Male kidney-specific BMAL1 knockout mice exhibited a substantially lower basal systolic blood pressure of 119 ± 2.3 mmHg compared to 127 ± 0.7 mmHg in control mice.

• BMAL1 is not expressed in key kidney segments involved in solute and fluid regulation in kidney-specific BMAL1 knockout mice.
• Female KS-BMAL1 KO mice did not show a difference in basal systolic blood pressure compared to controls.
• Male KS-BMAL1 KO mice retained 15% less sodium in response to a potassium-restricted diet compared to controls.
• No differences in sodium handling were observed in female mice following a potassium-restricted diet.
• There is evidence of a sex-specific response to potassium restriction, with female mice reabsorbing less sodium than male mice.

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