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Male kidney-specific BMAL1 knockout mice are protected from K+-deficient, high-salt diet-induced blood pressure increases
Male mice without kidney BMAL1 gene are protected from blood pressure rise caused by low potassium and high salt diet
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Abstract
Male kidney-specific BMAL1 knockout mice exhibit lower blood pressure on a low-Khigh-salt diet compared to control mice.
- The circadian clock protein BMAL1 may influence blood pressure regulation and immune responses in the kidneys.
- Male KS-BMAL1 knockout mice show a significant reduction in blood pressure when consuming a low-Khigh-salt diet.
- Despite lower blood pressure, the circadian rhythm in blood pressure remains unchanged in KS-BMAL1 knockout mice.
- Knockout mice have lower levels of renal proinflammatory cytokines and immune cells in response to the salt-sensitive diet.
- These findings suggest a protective effect of BMAL1 deletion against salt-sensitive hypertension and associated immune responses.
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