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Circadian Rhythm Disruption and Alzheimer’s Disease: The Dynamics of a Vicious Cycle
How Disrupted Body Clocks and Alzheimer’s Disease May Worsen Each Other
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Abstract
Circadian rhythm disruption is prevalent in contemporary society and is reported from the early stages of Alzheimer's disease (AD).
- Mammalian cells exhibit circadian rhythms in metabolism and energetics.
- New pathways of circadian timekeeping include non-transcriptional oscillations, post-translational modifications, epigenetics, and cellular signaling.
- Circadian rhythm disruption may contribute to neurodegeneration and is linked to various factors such as light-noise, shift work, and transmeridian travel.
- Bright light therapy combined with chronobiotics may be beneficial for treating cognitive symptoms in advanced AD patients.
- Potential targets for future management of AD include clock proteins and clock-controlled proteins.
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