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The circadian rhythm of melatonin in hypothyroidism and hyperthyroidism
Daily Melatonin Patterns in Underactive and Overactive Thyroid Conditions
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Abstract
In 16 women with thyroid disorders, the circadian rhythm of melatonin secretion is not altered compared to healthy controls.
- A significant melatonin circadian rhythm was observed in all groups: hypothyroid patients, hyperthyroid patients, and healthy controls.
- Melatonin rhythm parameters, including average levels (mesor), amplitude, and peak timing (acrophase), did not show significant differences across the groups.
- Integrated 24-hour melatonin secretion was similar among patients with thyroid disorders and healthy individuals.
- In hypothyroid patients, melatonin concentrations were positively correlated with thyroid-stimulating hormone (TSH) levels.
- In hyperthyroid patients, melatonin concentrations were negatively correlated with triiodothyronine (T3) levels.
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