Cell communication and signaling : CCS

The role of daily body clock proteins in stress from oxidation, immune response, and cancer development

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗OA ↗

Updated

Abstract

The PERIOD proteins () significantly influence physiological processes, including and immune functionality.

  • PER proteins are crucial for regulating the circadian clock, affecting various physiological and behavioral processes.
  • PER1 interacts with GPX1 to coordinate mitochondrial dynamics and energy management in relation to daily rhythms.
  • In innate immune cells, PERs affect the activity patterns of inflammatory markers NF-κB and TNF-α, influencing responses to toxic shock.
  • PERs can alter cancer cell behaviors, impacting proliferation, apoptosis, and migration through oncogene expression.
  • PER2 and PER3 act as antagonists in cancer stem cell biology, influencing differentiation and maintenance of stemness.
  • The expression levels of PERs may serve as significant indicators for early cancer diagnosis and prognosis.

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Funding

Competing interests

Declarations. Competing interests: The authors declare no competing interests.
PubMed

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