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PER1 interaction with GPX1 regulates metabolic homeostasis under oxidative stress
How PER1 and GPX1 work together to control metabolism during oxidative stress
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Abstract
Daily oxygen consumption rhythms were deregulated in Per1 deficient mice.
- Per1 deficiency led to impaired daily mitochondrial dynamics.
- Cellular fluctuations of reactive oxygen species (ROS) related to GPx were disrupted in peripheral organs.
- PER1 was found to enhance GPx activity through its interaction with GPX1 in the cytoplasm.
- Improved oxidative phosphorylation efficiency in mitochondria is associated with the activity of PER1.
- Per1 expression increased specifically in fasting peripheral organs, suggesting a protective role against oxidative stress.
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