Redox biology

How PER1 and GPX1 work together to control metabolism during oxidative stress

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Daily oxygen consumption rhythms were deregulated in Per1 deficient mice.

  • Per1 deficiency led to impaired daily mitochondrial dynamics.
  • Cellular fluctuations of reactive oxygen species (ROS) related to GPx were disrupted in peripheral organs.
  • PER1 was found to enhance GPx activity through its interaction with GPX1 in the cytoplasm.
  • Improved oxidative phosphorylation efficiency in mitochondria is associated with the activity of PER1.
  • Per1 expression increased specifically in fasting peripheral organs, suggesting a protective role against oxidative stress.

Simplified

Full Text

We can’t show the full text here under this license.
View Full Text ↗

Funding

Competing interests

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
PubMed

Related papers

Sep '14
USP2 controls where PER1 is located inside cells and affects daily gene activity
cited by 37 papers
research support, non-u.s. gov't
Jan '12
How Per1 and Dec1/2 genes work together to control daily movement patterns
cited by 16 papers
research support, non-u.s. gov't
Jan '22
Daily Rhythms Regulate Mitochondria to Balance Reactive Oxygen Levels
top 5% journal
cited by 90 papers
research support, n.i.h., extramural
Apr '14
The Tau mutation in casein kinase 1ε changes the body’s daily clock by controlling Period1 and Period2 proteins
cited by 43 papers
research support, non-u.s. gov't
Sep '19
Turning off Fubp1 disrupts daily cycles of Per1 protein by lowering Syncrip levels
top 20% journal
cited by 4 papers
journal article
Jun '21
Core body clock genes Per1 and Per2 control daily rhythm of light-sensing cell renewal
cited by 24 papers
research support, non-u.s. gov't

What Lands in Your Inbox Each Week:

  • 📚7 fresh studies
  • 📝plain-language summaries
  • ✅direct links to original studies
  • 🏅top journal indicators
  • 📅weekly delivery
  • 🧘‍♂️always free

Recent issues from the circadian biology brief

issue #49
Your body clock controls which drugs work — and a protein called gp78 is why
6 days ago7 studies
issue #48
A blood test can now estimate your internal clock time using just 60 proteins
1 week ago7 studies
issue #47
Your body clock controls liver fibrosis — and scientists just found the on/off switch
2 weeks ago7 studies
issue #46
Night shift workers' metabolomes fall out of sync — and glucose pays the price
3 weeks ago7 studies
issue #45
80% of FDA-approved drug targets show clock-dependent activity — timing may be everything
4 weeks ago7 studies
issue #44
Sleeping late on weekends is independently linked to higher cardiovascular disease risk
5 weeks ago7 studies
issue #43
A smartphone app cut mood episode recurrence 3.4x in people with depression and bipolar disorder
6 weeks ago7 studies
issue #42
Morning cancer immunotherapy linked to 49% vs 40% disease control rate in 969 patients
7 weeks ago7 studies
issue #41
Timing cancer treatment before 3pm nearly doubled survival in lung cancer patients
8 weeks ago7 studies
issue #40
Male mice lived 12% longer when they ate only during an 8-hour window at night
9 weeks ago7 studies
explore the archive
See more issues from the circadian biology brief