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CRISPR/Cas‐mediated Fubp1 silencing disrupts circadian oscillation of Per1 protein via downregulating Syncrip expression
Turning off Fubp1 disrupts daily cycles of Per1 protein by lowering Syncrip levels
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Abstract
The phasic profile of Per1 protein was clearly disrupted in CRISPR/Cas-mediated Fubp1-deficient cells.
- Core clock gene Period 1 (Per1) is essential for maintaining circadian rhythm duration in peripheral clocks.
- Alterations in Per1 expression and oscillation patterns are linked to cancer development and circadian rhythm abnormalities.
- Fubp1 enhances the mRNA and protein levels of Syncrip, which regulates Per1 protein oscillation.
- Fubp1 does not exhibit rhythmic expression but plays a role in the molecular clock system.
- Fubp1 is also associated with various physiological functions, including cell-cycle regulation and metabolic control.
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