Cell biology international

Turning off Fubp1 disrupts daily cycles of Per1 protein by lowering Syncrip levels

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

The phasic profile of Per1 protein was clearly disrupted in CRISPR/Cas-mediated Fubp1-deficient cells.

  • Core clock gene Period 1 (Per1) is essential for maintaining circadian rhythm duration in peripheral clocks.
  • Alterations in Per1 expression and oscillation patterns are linked to cancer development and circadian rhythm abnormalities.
  • Fubp1 enhances the mRNA and protein levels of Syncrip, which regulates Per1 protein oscillation.
  • Fubp1 does not exhibit rhythmic expression but plays a role in the molecular clock system.
  • Fubp1 is also associated with various physiological functions, including cell-cycle regulation and metabolic control.

Simplified

Full Text

Full text is available at the source.
View Full Text ↗

Related papers

Sep '14
USP2 controls where PER1 is located inside cells and affects daily gene activity
cited by 37 papers
research support, non-u.s. gov't
Nov '11
Daily rhythm between Period1 RNA and hnRNP Q controls time-based protein production
top 20% journal
cited by 62 papers
research support, non-u.s. gov't
Apr '20
The Related Proteins KLF9 and KLF13 Control the Daily Rhythm Gene Dbp in Mammal Cells
cited by 17 papers
research support, n.i.h., extramural
Sep '15
Mitomycin C changes daily rhythms of a clock gene by reducing stress hormone signals in mouse cells
top 30% journal
cited by 6 papers
research support, non-u.s. gov't
Mar '16
Increased Per1 levels controlled by miR-34a reduce bile duct cancer growth
top 1% journal
cited by 75 papers
research support, n.i.h., extramural
Jan '12
How Per1 and Dec1/2 genes work together to control daily movement patterns
cited by 16 papers
research support, non-u.s. gov't

What Lands in Your Inbox Each Week:

  • 📚7 fresh studies
  • 📝plain-language summaries
  • ✅direct links to original studies
  • 🏅top journal indicators
  • 📅weekly delivery
  • 🧘‍♂️always free

Recent issues from the circadian biology brief

issue #49
Your body clock controls which drugs work — and a protein called gp78 is why
6 days ago7 studies
issue #48
A blood test can now estimate your internal clock time using just 60 proteins
1 week ago7 studies
issue #47
Your body clock controls liver fibrosis — and scientists just found the on/off switch
2 weeks ago7 studies
issue #46
Night shift workers' metabolomes fall out of sync — and glucose pays the price
3 weeks ago7 studies
issue #45
80% of FDA-approved drug targets show clock-dependent activity — timing may be everything
4 weeks ago7 studies
issue #44
Sleeping late on weekends is independently linked to higher cardiovascular disease risk
5 weeks ago7 studies
issue #43
A smartphone app cut mood episode recurrence 3.4x in people with depression and bipolar disorder
6 weeks ago7 studies
issue #42
Morning cancer immunotherapy linked to 49% vs 40% disease control rate in 969 patients
7 weeks ago7 studies
issue #41
Timing cancer treatment before 3pm nearly doubled survival in lung cancer patients
8 weeks ago7 studies
issue #40
Male mice lived 12% longer when they ate only during an 8-hour window at night
9 weeks ago7 studies
explore the archive
See more issues from the circadian biology brief