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Rhythmic Interaction between Period1 mRNA and hnRNP Q Leads to Circadian Time-Dependent Translation
Daily rhythm between Period1 RNA and hnRNP Q controls time-based protein production
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Abstract
The circadian expression of mPER1 is regulated by rhythmic translational control of mPer1 mRNA.
- An internal ribosomal entry site (IRES) in the 5' untranslated region of mPer1 mRNA is involved in its rhythmic translation.
- Mouse heterogeneous nuclear ribonucleoprotein Q (mhnRNP Q) acts as a trans-acting factor that influences the translation of mPer1.
- Knockdown of mhnRNP Q leads to reduced mPER1 levels and a slight delay in its expression without altering mRNA levels.
- The translation rate of mPer1 mRNA shows phase-dependent characteristics due to rhythmic interactions with mhnRNP Q.
- Evidence for posttranscriptional regulation of core clock genes indicates that both translation and transcription contribute to circadian rhythmicity.
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