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Rhythmic control of AANAT translation by hnRNP Q in circadian melatonin production
Daily rhythmic control of melatonin-making enzyme production by hnRNP Q protein
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Abstract
The protein expression of AANAT peaks in the middle of the night, influencing melatonin production.
- AANAT protein expression is regulated by rhythmic translation of its mRNA.
- An internal ribosome entry site (IRES) in the AANAT mRNA plays a crucial role in this regulation.
- The partner protein, hnRNP Q, is involved in enhancing AANAT IRES activities.
- Knockdown of hnRNP Q significantly decreases AANAT protein levels and melatonin production.
- This mechanism offers new insights into how vertebrate melatonin's circadian rhythm is achieved.
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