Genes & development

Daily rhythmic control of melatonin-making enzyme production by hnRNP Q protein

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

The protein expression of AANAT peaks in the middle of the night, influencing melatonin production.

  • AANAT protein expression is regulated by rhythmic translation of its mRNA.
  • An internal ribosome entry site (IRES) in the AANAT mRNA plays a crucial role in this regulation.
  • The partner protein, hnRNP Q, is involved in enhancing AANAT IRES activities.
  • Knockdown of hnRNP Q significantly decreases AANAT protein levels and melatonin production.
  • This mechanism offers new insights into how vertebrate melatonin's circadian rhythm is achieved.

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