Molecular and cellular biology

Regular breakdown of serotonin enzyme messages is needed to keep its daily rhythm

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Three proteins were identified that may regulate the degradation of AANAT mRNA involved in melatonin synthesis.

  • Heterogeneous nuclear ribonucleoprotein R (hnRNP R), hnRNP Q, and hnRNP L associate with specific regions of AANAT mRNA.
  • These proteins have an RNA-destabilizing function that influences the stability of AANAT mRNA.
  • Expression levels of these proteins in pineal glands exhibit a robust circadian rhythm.
  • Increased levels of these proteins after midnight correlate with a significant decline in AANAT mRNA.
  • A mathematical model suggests that the rhythmic degradation of AANAT mRNA is crucial for its circadian regulation.

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