Rhythmic Serotonin N -Acetyltransferase mRNA Degradation Is Essential for the Maintenance of Its Circadian Oscillation

Mar 31, 2005Molecular and cellular biology

Regular breakdown of serotonin enzyme messages is needed to keep its daily rhythm

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Abstract

Three proteins were identified that may regulate the degradation of AANAT mRNA involved in melatonin synthesis.

  • Heterogeneous nuclear ribonucleoprotein R (hnRNP R), hnRNP Q, and hnRNP L associate with specific regions of AANAT mRNA.
  • These proteins have an RNA-destabilizing function that influences the stability of AANAT mRNA.
  • Expression levels of these proteins in pineal glands exhibit a robust circadian rhythm.
  • Increased levels of these proteins after midnight correlate with a significant decline in AANAT mRNA.
  • A mathematical model suggests that the rhythmic degradation of AANAT mRNA is crucial for its circadian regulation.

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