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Heterogeneous ribonucleoprotein R regulates arylalkylamine N‐acetyltransferase synthesis via internal ribosomal entry site‐mediated translation in a circadian manner
How a protein controls daily production of an enzyme using a special protein-making process
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Abstract
AANAT protein synthesis is influenced by the rhythmic levels of the RNA-binding protein hnRNP R.
- Heterogeneous ribonucleoprotein R (hnRNP R) interacts with the 5' untranslated region of AANAT mRNA.
- hnRNP R contributes to the translation of AANAT through an internal ribosomal entry site.
- Knockdown and overexpression of hnRNP R fine-tunes AANAT protein synthesis.
- AANAT protein levels elevate at night, correlating with increased hnRNP R in the pineal gland.
- Enhanced AANAT production in rat pinealocytes occurs with elevated hnRNP R levels under norepinephrine treatment.
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