Norepinephrine activates NF-κB transcription factor in cultured rat pineal gland

Norepinephrine activates the p50/p50 homodimer of NF-κB, which is involved in melatonin synthesis.

• Norepinephrine interacts with β1-adrenoceptors, which activates a signaling cascade affecting melatonin production.
• The p50/p50 homodimer of NF-κB is activated by norepinephrine in rat pineal glands.
• NF-κB activation influences the transcription and activity of the enzyme AANAT, essential for melatonin synthesis.
• Evidence suggests that NF-κB may directly or indirectly modulate Aanat transcription and activity.
• Norepinephrine potentially affects the movement of the NF-κB p50/p50 homodimer into the nucleus of pinealocytes.

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