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Circadian rhythm: The hidden “puppet master” behind musculoskeletal disorders
How the Body’s Internal Clock May Influence Muscle and Bone Disorders
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Abstract
Circadian rhythm (CR) is linked to the physiology of the musculoskeletal system.
- CR is regulated by the central biological clock in the hypothalamus and local clocks in peripheral tissues.
- Disruptions in CR may contribute to the development of musculoskeletal disorders through various pathways.
- Modern behaviors, such as traveling across time zones and irregular eating, can desynchronize CR.
- The review highlights the mechanisms by which CR disruption affects bone, cartilage, tendons, and muscles.
- Interventions discussed include resetting biological clocks and optimizing the timing of medication administration.
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