Circadian rhythms and exercise — re-setting the clock in metabolic disease

Jan 19, 2019Nature reviews. Endocrinology

Exercise and body clock rhythms in metabolic disease

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Abstract

Exercise timing may enhance health benefits for individuals with metabolic diseases.

  • Perturbed daily rhythms are linked to metabolic disease pathology.
  • Skeletal muscle metabolism is influenced by the body's internal clock.
  • Mitochondrial function in humans peaks in the late afternoon.
  • Exercise could serve as a time cue to improve metabolic health.
  • Shift work is associated with increased insulin resistance.
  • Timed exercise may improve health markers for shift workers at risk of metabolic disease.

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