Circadian rhythms and glucocorticoid dynamics in the kidney matrix

No SJR dataJan 29, 2026Nephron

Daily body clock and stress hormone patterns in the kidney support structure

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Circadian Biology on OpenScience ↗PubMed ↗DOI ↗OA ↗

Abstract

The kidney matrix is a dynamic environment that undergoes continual remodelling influenced by circadian rhythms.

Circadian patterns in kidney remodelling are driven by molecular clocks in specific kidney cell types.
In the glomerulus, these clocks regulate the timing of matrix turnover, which is essential for maintaining filtration and structural integrity.
Disruption of circadian rhythms may lead to maladaptive matrix accumulation and contribute to kidney disease progression.
Recent advances offer mechanistic insights and potential translational opportunities, such as chronotherapy.
Understanding circadian control of glomerular matrix dynamics could link temporal biology to kidney health.

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The kidney matrix, once viewed as a static scaffold, is now recognised as a dynamic microenvironment that undergoes continual remodelling in response to physiological cues. Emerging evidence demonstrates that this remodelling follows circadian patterns driven by molecular clocks within specific kidney cell types. This review synthesises recent advances on circadian regulation of the kidney matrisome, with emphasis on glomerular compartments. Circadian clocks in the glomerulus coordinate the timing of matrix turnover to preserve structural integrity, maintain filtration, and promote repair. Disruption of these rhythms contributes to maladaptive matrix accumulation, fibrosis, and kidney disease progression. Finally, we discuss mechanistic insights and translational opportunities, including chronotherapy and clock-targeted interventions. Understanding circadian control of glomerular matrix dynamics provides a framework for linking temporal biology to kidney health and disease.

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