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Daily body clock patterns in children's aggressive brain tumors may affect treatment success
Updated
Abstract
Pediatric high-grade gliomas (pHGG) show significantly higher levels of BMAL1 protein compared to low-grade gliomas (pLGG).
- Circadian genes are rhythmically expressed in pHGG lines, unlike in pLGG specimens.
- Higher Bmal1 expression and lower Rev-Erbα expression were observed in pHGG compared to pLGG tissues.
- Temozolomide treatment during peak Bmal1 expression resulted in significantly decreased tumor cell proliferation.
- The positive arm of the circadian clock, represented by BMAL1 and CLOCK, appears upregulated in pHGGs.
Simplified
Key numbers
44%
Decrease in Proliferation
Proliferation decreased when TMZ was applied at trough vs. peak Bmal1 expression.
3.334 vs. 3.005
Higher mRNA Expression
mRNA levels of Bmal1 were significantly higher in pHGGs than in pLGGs.