How the Body Clock Influences SIRT1 Activity: Computer Models and Lab Experiments

SIRT1 is shown to positively regulate circadian clock function through its actions on PER2 and PGC1α.

• Circadian rhythms are maintained by a negative transcriptional feedback loop at the molecular level.
• SIRT1 directly affects the acetylation status of clock components, which in turn influences circadian amplitude in cells.
• The model developed aligns with previous findings, highlighting PER2 as the primary target of SIRT1.
• SIRT1 may influence gene expression related to circadian rhythms through its effects on PGC1α.
• Experimental validation supports the computational model's predictions regarding SIRT1's role in clock regulation.

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