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Effect of H2S on the circadian rhythm of mouse hepatocytes
Hydrogen sulfide’s effects on daily rhythms in mouse liver cells
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Abstract
Exogenous hydrogen sulfide (H₂S) significantly increased the expression level of sirtuin-1 (SIRT1) in isolated liver cells.
- Circadian clock genes such as Clock, Per2, Bmal1, and Rev-erbα displayed a gradual decrease in expression levels and peak amplitude in hepatocytes without H₂S.
- H₂S treatment maintained the expression and amplitude of these circadian clock genes over a certain period.
- The expression level of SIRT1 was significantly higher in the H₂S group compared to the control group.
- It is suggested that H₂S may alter the NAD+/NADH content ratio in hepatocytes.
- Changes in SIRT1 activity could help preserve the circadian rhythm of clock gene expression, potentially influencing lipid metabolism.
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