Full text is available at the source.
Differential effects of the circadian system and circadian misalignment on insulin sensitivity and insulin secretion in humans
How the body’s internal clock and its disruption differently affect insulin response and release in people
AI simplified
Abstract
Circadian phase and misalignment significantly impact glucose tolerance and β-cell responsivity.
- Glucose tolerance is lower at night and higher in the morning.
- Circadian phase affects glucose tolerance primarily by reducing β-cell responsivity.
- Circadian misalignment lowers insulin sensitivity without influencing β-cell function.
- Different mechanisms are involved in how the circadian system and misalignment impact glucose control.
AI simplified