Circadian Controlled Transcription in Brain and Peripheral Organs of Juvenile and Adult Mice

Rhythmic transcription phases in C57BL6/J mice cluster near dawn and dusk in all organs except the testis.

• Circadian transcription was quantified using genome-wide eXcision Repair sequencing (XR-seq) in various organs.
• Core clock gene rhythms are largely preserved in both juvenile and adult mice.
• Significant differences exist in the rhythms of many clock-controlled genes between juveniles and adults.
• Gene rhythms show strong organ-specificity, with limited overlap in rhythmic genes across ages.
• These findings suggest substantial developmental changes in circadian control that may affect therapeutic scheduling.

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