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Transcription factor activity rhythms and tissue-specific chromatin interactions explain circadian gene expression across organs
Daily rhythms in gene regulators and tissue-specific DNA packaging explain 24-hour gene activity in different organs
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Abstract
Two distinct regulatory modes underlie tissue-specific rhythms in mouse physiology.
- Tissue-specific oscillations in transcription factor activity are linked to feeding-fasting cycles in the liver and sodium homeostasis in the kidney.
- Clock and tissue-specific transcription factors colocalize at distal enhancers, influencing gene expression.
- Chromosome conformation capture identified liver-specific chromatin loops that connect clock-bound enhancers to liver-specific promoters.
- This chromatin looping is promoter-specific and occurs within a distance of less than 10 kilobases.
- Enhancers can selectively contact rhythmic promoters while excluding nearby nonrhythmic alternatives, highlighting spatial regulation of gene expression.
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