Full text is available at the source.
Abstract
Glucocorticoid receptor (GR) binding in mouse livers shows a rhythmic pattern that correlates with metabolic processes across the day-night cycle.
- GR regulates metabolic processes through time-dependent control of target gene expression.
- Differential regulation occurs for circulating glucose and triglycerides during feeding and fasting states.
- Most oscillating genes are bound by GR, indicating its significant role in circadian rhythms.
- High-fat diets alter the rhythmic pattern of gene expression without affecting GR's binding to DNA.
- In obese mice, increased co-occupancy of the protein STAT5 with GR was observed, influencing gene expression.
Simplified