Clinical significance of social jetlag in patients with excessive daytime sleepiness

Patients with narcolepsy (n = 39), behaviorally induced insufficient sleep syndrome (BIISS) (n = 87), and delayed sleep-wake phase disorder (DSPD) (n = 28) showed varying associations between social jetlag and daytime sleepiness.

• Social jetlag levels were negatively correlated with physical health-related quality of life in patients with narcolepsy.
• In patients with DSPD, social jetlag was positively correlated with subjective sleepiness as measured by the Epworth sleepiness scale.
• For patients with BIISS, social jetlag reflected sleep loss rather than circadian misalignment and was not associated with daytime sleepiness.
• Social jetlag did not correlate with mistakes in daily activities, traffic accidents, or near-miss events across the groups.
• The impact of social jetlag on daily functioning differed among narcolepsy, BIISS, and DSPD patients.

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