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Association between CLOCK 3111T/C and preferred circadian phase in Korean patients with bipolar disorder
Link between a common CLOCK gene variation and sleep-wake preference in Korean bipolar disorder patients
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Abstract
CLOCK 3111T/C showed significant allelic and genotypic associations with bipolar disorder in 260 patients and 350 controls.
- The SNP 3111T/C in the CLOCK gene is linked to bipolar disorder, with P-values of 0.012 for allelic and 0.033 for genotypic associations.
- In a subgroup of 108 bipolar disorder patients, C allele carriers were more prevalent among extreme evening types compared to extreme morning types (P=0.041).
- C allele carriers had lower scores on the Composite Scale of Morningness than T/T genotype carriers, though this finding was not statistically significant.
- No association was found between age at onset of bipolar disorder and CLOCK 3111T/C in the studied group.
- Results suggest a potential role for the CLOCK 3111T/C SNP in bipolar disorder, although the sample sizes were relatively small.
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